Tianqing Peng Selected Research

calpastatin

1/2021	Calpain Activation and Organ Failure in Sepsis: Molecular Insights and Therapeutic Perspectives.
1/2020	Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production.
9/2015	Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
7/2015	Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes.
5/2015	Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation.
6/2013	Over-expression of calpastatin aggravates cardiotoxicity induced by doxorubicin.
11/2011	Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes.
6/2009	Calpain-1 induces apoptosis in pulmonary microvascular endothelial cells under septic conditions.

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Tianqing Peng Research Topics

Disease

18	Sepsis (Septicemia) 12/2023 - 02/2005
12	Inflammation (Inflammations) 12/2023 - 08/2012
10	Diabetic Cardiomyopathies 01/2022 - 10/2009
9	Hypertrophy 02/2022 - 08/2010
8	Endotoxemia 01/2020 - 10/2003
6	Fibrosis (Cirrhosis) 02/2022 - 08/2010
5	Heart Failure 01/2022 - 08/2002
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2019 - 08/2010
5	Necrosis 01/2011 - 04/2008
4	Infections 01/2024 - 01/2012
4	Mitochondrial Diseases (Mitochondrial Disease) 12/2023 - 01/2019
4	Cardiomyopathies (Cardiomyopathy) 01/2022 - 10/2011
4	Hyperglycemia 01/2022 - 10/2009
4	Heart Diseases (Heart Disease) 01/2021 - 10/2009
4	Cardiotoxicity 01/2019 - 01/2013
4	Hypoxia (Hypoxemia) 05/2015 - 02/2007
3	Ischemia 01/2020 - 02/2005
3	Cardiomegaly (Heart Hypertrophy) 01/2019 - 08/2015
3	Myocarditis (Carditis) 01/2014 - 12/2011
2	Acute Kidney Injury (Acute Renal Failure) 01/2020 - 12/2019
2	Type 2 Diabetes Mellitus (MODY) 01/2019 - 10/2016
2	Heart Injuries 01/2018 - 05/2015
2	Reperfusion Injury 07/2015 - 12/2010
2	Cardiovascular Diseases (Cardiovascular Disease) 06/2013 - 12/2011
2	Heart Neoplasms 08/2009 - 04/2008
1	Obesity 02/2022
1	Hyperlipidemias (Hyperlipidemia) 01/2022
1	Hyperinsulinism (Hyperinsulinemia) 01/2022
1	Atrophy 01/2022
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2022
1	Systemic Scleroderma (Systemic Sclerosis) 01/2022
1	Sclerosis 01/2022
1	Multiple Organ Failure (MODS) 01/2021
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2020
1	Microvascular Rarefaction 01/2019
1	Neoplasms (Cancer) 01/2019
1	Prediabetic State (Prediabetes) 01/2019

Drug/Important Bio-Agent (IBA)

16	CalpainIBA 01/2022 - 06/2009
11	LipopolysaccharidesIBA 01/2023 - 04/2005
9	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2010 - 10/2003
8	Proteins (Proteins, Gene)FDA Link 01/2023 - 08/2012
8	calpastatinIBA 01/2021 - 06/2009
7	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 10/2009
6	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2013 - 02/2007
5	Therapeutic UsesIBA 12/2023 - 01/2011
4	Caspase 3 (Caspase-3)IBA 12/2023 - 07/2009
4	Adenosine Triphosphate (ATP)IBA 02/2022 - 09/2015
4	CytokinesIBA 01/2022 - 01/2011
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019 - 01/2013
4	Sirtuin 1IBA 01/2019 - 08/2015
4	MicroRNAs (MicroRNA)IBA 05/2016 - 10/2011
3	NAD (NADH)IBA 12/2023 - 01/2018
3	Streptozocin (Streptozotocin)FDA Link 01/2022 - 10/2009
3	Superoxides (Superoxide)IBA 01/2019 - 09/2015
2	VaccinesIBA 01/2024 - 01/2013
2	Sirtuin 3IBA 12/2023 - 12/2019
2	EndotoxinsIBA 01/2023 - 01/2020
2	LipocalinsIBA 01/2023 - 01/2022
2	LipidsIBA 02/2022 - 11/2016
2	AntioxidantsIBA 01/2020 - 01/2016
2	calpain inhibitorsIBA 01/2020 - 07/2015
2	TEMPOIBA 01/2019 - 01/2016
2	nicotinamide-beta-ribosideIBA 01/2019 - 01/2018
2	HMGB1 Protein (HMG1)IBA 01/2018 - 12/2011
2	Interleukin-6 (Interleukin 6)IBA 01/2013 - 01/2011
2	acetovanillone (apocynin)IBA 08/2010 - 10/2009
2	p38 Mitogen-Activated Protein KinasesIBA 08/2009 - 10/2003
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 11/2008 - 02/2007
2	1- (6- ((3- methoxyestra- 1,3,5(10)- trien- 17- yl)amino)hexyl)- 1H- pyrrole- 2,5- dioneIBA 04/2008 - 09/2007
2	NADH oxidaseIBA 04/2005 - 02/2005
1	Lactic Acid (Lactate)FDA LinkGeneric 12/2023
1	Nicotinamide MononucleotideIBA 12/2023
1	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2023
1	Mitochondrial DNA (mtDNA)IBA 02/2022
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2022
1	Atorvastatin (Lipitor)FDA Link 01/2022
1	ChemokinesIBA 01/2022
1	NSC 23766IBA 01/2022
1	PD 150606IBA 01/2022
1	indium-bleomycinIBA 01/2022
1	Protein Isoforms (Isoforms)IBA 10/2021
1	PotassiumIBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Insulin (Novolin)FDA Link 01/2020
1	glucose-insulin-potassium cardioplegic solutionIBA 01/2020
1	Cisplatin (Platino)FDA LinkGeneric 12/2019
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 12/2019
1	Superoxide DismutaseIBA 01/2019
1	Endosomal Sorting Complexes Required for TransportIBA 01/2019
1	Tsg101 proteinIBA 01/2019
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2019
1	IGF Type 1 Receptor (IGF 1 Receptor)IBA 01/2019
1	Small Interfering RNA (siRNA)IBA 01/2019
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2019
1	CateninsIBA 01/2019
1	Monensin (Coban)IBA 01/2019
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2019

Therapy/Procedure

6	Therapeutics 12/2023 - 01/2011
2	Ligation 01/2023 - 09/2015
2	Punctures 01/2023 - 09/2015